The self-assembly and evolution of homomeric protein complexes
نویسندگان
چکیده
Gabriel Villar, Alex W. Wilber, Alex J. Williamson, Parvinder Thiara, Jonathan P. K. Doye, ∗ Ard A. Louis, Mara N. Jochum, Anna C. F. Lewis, and Emmanuel D. Levy Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, United Kingdom Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford, OX1 3NP, United Kingdom MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom (Dated: November 22, 2008)
منابع مشابه
Self-assembly and evolution of homomeric protein complexes.
We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes i...
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تاریخ انتشار 2008